| 主权项 |
1. A compound corresponding to formula (I) wherein X represents CR3 or N, wherein
R3 represents H; C1-10 alkyl, saturated or unsaturated, branched or unbranched, unsubstituted or mono- or polysubstituted; A represents N or CR5b, n represents 1, 2, 3 or 4; R0 represents C1-10 alkyl, saturated or unsaturated, branched or unbranched, unsubstituted or mono- or polysubstituted; C3-10 cycloalkyl or heterocyclyl, respectively saturated or unsaturated, unsubstituted or mono- or polysubstituted; aryl or heteroaryl, respectively unsubstituted or mono- or polysubstituted; C3-10 cycloalkyl or heterocyclyl bridged via C1-8 alkyl, respectively saturated or unsaturated, unsubstituted or mono- or polysubstituted, wherein the alkyl chain can be respectively branched or unbranched, saturated or unsaturated, unsubstituted, mono- or polysubstituted; or aryl or heteroaryl bridged via C1-8 alkyl, respectively unsubstituted or mono- or polysubstituted, wherein the alkyl chain can be respectively branched or unbranched, saturated or unsaturated, unsubstituted, mono- or polysubstituted; R1 represents C1-10 alkyl, saturated or unsaturated, branched or unbranched, unsubstituted or mono- or polysubstituted; C3-10 cycloalkyl1 or heterocyclyl1, respectively saturated or unsaturated, unsubstituted or mono- or polysubstituted; aryl or heteroaryl, respectively unsubstituted or mono- or polysubstituted; C3-10 cycloalkyl1 or heterocyclyl1 bridged via C1-8 alkyl, respectively saturated or unsaturated, unsubstituted or mono- or polysubstituted, wherein the alkyl chain can be respectively branched or unbranched, saturated or unsaturated, unsubstituted, mono- or polysubstituted; or aryl or heteroaryl bridged via C1-8 alkyl, respectively unsubstituted or mono- or polysubstituted, wherein the alkyl chain can be respectively branched or unbranched, saturated or unsaturated, unsubstituted, mono- or polysubstituted; C(═O)—R0; C(═O)—OH; C(═O)—OR0; C(═O)—NHR0; C(═O)—N(R0)2; OH; O—R0; SH; S—R0; S(═O)2—R0; S(═O)2—OR0; S(═O)2—NHR0; S(═O)2—N(R0)2; NH2; NHR0; N(R0)2; NH—S(═O)2—R0; N(R0)(S(═O)2—R0); or SCl3; R2 represents H; R0; F; I; CN; NO2; OH; SH; CF3; CF2H; CFH2; CF2Cl; CFCl2; CH2CF3; OCF3; OCF2H; OCFH2; OCF2Cl; OCFCl2; SCF3; SCF2H; SCFH2; SCF2Cl; SCFCl2; S(═O)2—CF3; S(═O)2—CF2H; S(═O)2—CFH2; or SF5; R4 represents H; F; Cl; Br; I; OH; C1-10 alkyl, saturated or unsaturated, branched or unbranched, unsubstituted or mono- or polysubstituted; R5a represents H; OH; C1-10 alkyl, saturated or unsaturated, branched or unbranched, unsubstituted or mono- or polysubstituted; R5b represents H or R0; or R5a and R5b together with the carbon atom connecting them form a C3-10 cycloalkyl or a heterocyclyl, respectively saturated or unsaturated, unsubstituted or mono- or polysubstituted; R6, R7, R9 and R10 each independently represent H; F; Cl; Br; I; NO2; CN; CF3; CF2H; CFH2; CF2Cl; CFCl2; R0; C(═O)H; C(═O)R0; CO2H; C(═O)OR0; CONH2; C(═O)NHR0; C(═O)N(R0)2; OH; OCF3; OCF2H; OCFH2; OCF2Cl; OCFCl2; OR0; O—C(═O)—R0; O—C(═O)—O—R0; O—(C═O)—NH—R0; O—C(═O)—N(R0)2; O—S(═O)2—R0; O—S(═O)2OH; O—S(═O)2OR0; O—S(═O)2NH2; O—S(═O)2NHR0; O—S(═O)2N(R0)2; NH2; NH—R0; N(R0)2; NH—C(═O)—R0; NH—C(═O)—O—R0; NH—C(═O)—NH2; NH—C(═O)—NH—R0; NH—C(═O)—N(R0)2; NR0—C(═O)—R0; NR0—C(═O)—O—R0; NR0—C(═O)—NH2; NR0—C(═O)—NH—R0; NR0—C(═O)—N(R0)2; NH—S(═O)2OH; NH—S(═O)2R0; NH—S(═O)2OR0; NH—S(═O)2NH2; NH—S(═O)2NHR0; NH—S(═O)2N(R0)2; NR0—S(═O)2OH; NR0—S(═O)2R0; NR0—S(═O)2OR0; NR0—S(═O)2NH2; NR0—S(═O)2NHR0; NR0—S(═O)2N(R0)2; SH; SCF3; SCF2H; SCFH2; SCF2Cl; SCFCl2; SR0; S(═O)R0; S(═O)2R0; S(═O)2OH; S(═O)2OR0; S(═O)2NH2; S(═O)2NHR0; or S(═O)2N(R0)2; R8 represents H; F; Cl; Br; I; NO2; CN; CF3; CF2H; CFH2; CF2Cl; CFCl2; R0; C(═O)H; C(═O)R0; CO2H; C(═O)OR0; CONH2; C(═O)NHR0; C(═O)N(R0)2; OH; OCF3; OCF2H; OCFH2; OCF2Cl; OCFCl2; OR0; O—C(═O)—R0; O—C(═O)—O—R0; O—(C═O)—NH—R0; O—C(═O)—N(R0)2; O—S(═O)2—R0; O—S(═O)2OH; O—S(═O)2OR0; O—S(═O)2NH2; O—S(═O)2NHR0; O—S(═O)2N(R0)2; NH2; NH—R0; N(R0)2; NH—C(═O)—R0; NH—C(═O)—O—R0; NH—C(═O)—NH2; NH—C(═O)—NH—R0; NH—C(═O)—N(R0)2; NR0—C(═O)—R0; NR0—C(═O)—O—R0; NR0—C(═O)—NH2; NR0—C(═O)—NH—R0; NR0—C(═O)—N(R0)2; NH—S(═O)2OH; NH—S(═O)2R0; NH—S(═O)2OR0; NH—S(═O)2NH2; NH—S(═O)2NHR0; NH—S(═O)2N(R0)2; NR0—S(═O)2OH; NR0—S(═O)2R0; NR0—S(═O)2OR0; NR0—S(═O)2NH2; NR0—S(═O)2NHR0; NR0—S(═O)2N(R0)2; SH; SCF3; SCF2H; SCFH2; SCF2Cl; SCFCl2; SR0; S(═O)R0; S(═O)2R0; S(═O)2OH; S(═O)2OR0; S(═O)2NH2; S(═O)2NHR0; or S(═O)2N(R0)2; wherein, if R8 denotes R0 and R0 represents heteroaryl, said heteroaryl is selected from the group consisting of benzofuranyl, benzoimidazolyl, benzothienyl, benzothiadiazolyl, benzothiazolyl, benzotriazolyl, benzooxazolyl, benzooxadiazolyl, quinazolinyl, quinoxalinyl, carbazolyl, quinolinyl, dibenzofuranyl, dibenzothienyl, furyl (furanyl), imidazothiazolyl, indazolyl, indolizinyl, indolyl, isoquinolinyl, isoxazoyl, isothiazolyl, indolyl, naphthyridinyl, oxazolyl, oxadiazolyl, phenazinyl, phenothiazinyl, phthalazinyl, pyrazolyl, pyridyl (2-pyridyl, 3-pyridyl, 4-pyridyl), pyrrolyl, pyridazinyl, pyrimidinyl, pyrazinyl, purinyl, phenazinyl, thienyl (thiophenyl), triazolyl, tetrazolyl, thiazolyl, thiadiazolyl and triazinyl; wherein
“substituted alkyl”, “substituted heterocyclyl” and “substituted cycloalkyl” relate, with respect to the corresponding residues, to the replacement of one or more hydrogen atoms each independently by F; Cl; Br; I; NO2; CN; ═O; ═NH; ═C(NH2)2; CF3; CF2H; CFH2; CF2Cl; CFCl2; R0; C(═O)H; C(═O)R0; CO2H; C(═O)OR0; CONH2; C(═O)NHR0; C(═O)N(R0)2; OH; OCF3; OCF2H; OCFH2; OCF2Cl; OCFCl2; OR0; O—C(═O)—R0; O—C(═O)—O—R0; O—(C═O)—NH—R0; O—C(═O)—N(R0)2; O—S(═O)2—R0; O—S(═O)2OH; O—S(═O)2OR0; O—S(═O)2NH2; O—S(═O)2NHR0; O—S(═O)2N(R0)2; NH2; NH—R0; N(R0)2; NH—C(═O)—R0; NH—C(═O)—O—R0; NH—C(═O)—NH2; NH—C(═O)—NH—R0; NH—C(═O)—N(R0)2; NR0—C(═O)—R0; NR0—C(═O)—O—R0; NR0—C(═O)—NH2; NR0—C(═O)—NH—R0; NR0—C(═O)—N(R0)2; NH—S(═O)2OH; NH—S(═O)2R0; NH—S(═O)2OR0; NH—S(═O)2NH2; NH—S(═O)2NHR0; NH—S(═O)2N(R0)2; NR0—S(═O)2OH; NR0—S(═O)2R0; NR0—S(═O)2OR0; NR0—S(═O)2NH2; NR0—S(═O)2NHR0; NR0—S(═O)2N(R0)2; SH; SCF3; SCF2H; SCFH2; SCF2Cl; SCFCl2; SR0; S(═O)R0; S(═O)2R0; S(═O)2OH; S(═O)2OR0; S(═O)2NH2; S(═O)2NHR0; or S(═O)2N(R0)2;“substituted cycloalkyl1” and “substituted heterocyclyl1” relate, with respect to the corresponding residues, to the replacement of one or more hydrogen atoms each independently by F; Cl; Br; I; NO2; CN; ═O; ═C(NH2)2; CF3; CF2H; CFH2; CF2Cl; CFCl2; R0; C(═O)H; C(═O)R0; CO2H; C(═O)OR0; CONH2; C(═O)NHR0; C(═O)N(R0)2; OH; OCF3; OCF2H; OCFH2; OCF2Cl; OCFCl2; OR0; O—C(═O)—R0; O—C(═O)—O—R0; O—(C═O)—NH—R0; O—C(═O)—N(R0)2; O—S(═O)2—R0; O—S(═O)2OH; O—S(═O)2OR0; O—S(═O)2NH2; O—S(═O)2NHR0; O—S(═O)2N(R0)2; SH; SCF3; SCF2H; SCFH2; SCF2Cl; SCFCl2; SR0; S(═O)R0; S(═O)2R0; S(═O)2OH; S(═O)2OR0; S(═O)2NH2; S(═O)2NHR0; or S(═O)2N(R0)2;“substituted aryl” relates, with respect to the corresponding residues, to the replacement of one or more hydrogen atoms each independently by F; Cl; Br; I; NO2; CF3; CF2H; CFH2; CF2Cl; CFCl2; R0; C(═O)H; C(═O)R0; CO2H; C(═O)OR0; CONH2; C(═O)NHR0; C(═O)N(R0)2; OH; OCF3; OCF2H; OCFH2; OCF2Cl; OCFCl2; OR0; O—C(═O)—R0; O—C(═O)—O—R0; O—(C═O)—NH—R0; O—C(═O)—N(R0)2; O—S(═O)2—R0; O—S(═O)2OH; O—S(═O)2OR0; O—S(═O)2NH2; O—S(═O)2NHR0; O—S(═O)2N(R0)2; NH2; NH—R0; N(R0)2; NH—C(═O)—R0; NH—C(═O)—O—R0; NH—C(═O)—NH2; NH—C(═O)—NH—R0; NH—C(═O)—N(R0)2; NR0—C(═O)—R0; NR0—C(═O)—O—R0; NR0—C(═O)—NH2; NR0—C(═O)—NH—R0; NR0—C(═O)—N(R0)2; NH—S(═O)2OH; NH—S(═O)2R0; NH—S(═O)2OR0; NH—S(═O)2NH2; NH—S(═O)2NHR0; NH—S(═O)2N(R0)2; NR0—S(═O)2OH; NR0—S(═O)2R0; NR0—S(═O)2OR0; NR0—S(═O)2NH2; NR0—S(═O)2NHR0; NR0—S(═O)2N(R0)2; SH; SCF3; SCF2H; SCFH2; SCF2Cl; SCFCl2; SR0; S(═O)R0; S(═O)2R0; S(═O)2OH; S(═O)2OR0; S(═O)2NH2; S(═O)2NHR0; or S(═O)2N(R0)2; and “substituted heteroaryl” relates, with respect to the corresponding residues, to the replacement of one or more hydrogen atoms each independently by F; Cl; Br; I; NO2; CN; CF3; CF2H; CFH2; CF2Cl; CFCl2; R0; C(═O)H; C(═O)R0; CO2H; C(═O)OR0; CONH2; C(═O)NHR0; C(═O)N(R0)2; OH; OCF3; OCF2H; OCFH2; OCF2Cl; OCFCl2; OR0; O—C(═O)—R0; O—C(═O)—O—R0; O—(C═O)—NH—R0; O—C(═O)—N(R0)2; O—S(═O)2—R0; O—S(═O)2OH; O—S(═O)2OR0; O—S(═O)2NH2; O—S(═O)2NHR0; O—S(═O)2N(R0)2; NH2; NH—R0; N(R0)2; NH—C(═O)—R0; NH—C(═O)—O—R0; NH—C(═O)—NH2; NH—C(═O)—NH—R0; NH—C(═O)—N(R0)2; NR0—C(═O)—R0; NR0—C(═O)—O—R0; NR0—C(═O)—NH2; NR0—C(═O)—NH—R0; NR0—C(═O)—N(R0)2; NH—S(═O)2OH; NH—S(═O)2R0; NH—S(═O)2OR0; NH—S(═O)2NH2; NH—S(═O)2NHR0; NH—S(═O)2N(R0)2; NR0—S(═O)2OH; NR0—S(═O)2R0; NR0—S(═O)2OR0; NR0—S(═O)2NH2; NR0—S(═O)2NHR0; NR0—S(═O)2N(R0)2; SH; SCF3; SCF2H; SCFH2; SCF2Cl; SCFCl2; SR0; S(═O)R0; S(═O)2R0; S(═O)2OH; S(═O)2OR0; S(═O)2NH2; S(═O)2NHR0; or S(═O)2N(R0)2;in the form of a free compound; a tautomer; an N-oxide; a racemate; an enantiomer, a diastereomer, a mixture of enantiomers or diastereomers or a salt of a physiologically compatible acid or base. |
