2',3'-DIDEOXY-5-FLUOROURIDINE DERIVATIVES, A PROCESS FOR THE MANUFACTURE THEREOF AND APPLICATION THEREOF

摘要

The subject matter of the invention is novel 2',3'-dideoxy-5-fluorouridine derivatives of general formula 1. wherein: R1 denotes cinchona alkaloid fragment with defined absolute configuration at C-8 and C-9 atoms. In the second aspect, the subject matter of the invention is a process for the manufacture of 2',3'-dideoxy-5-fluorouridine derivatives of general formula 1. In the third aspect, the subject matter of the invention is an application of 2',3'-dideoxy-5-fluorouridine derivatives of general formula1 of the invention in the anticancer treatment of breast cancer, cervical cancer and hepatic cancer.