发明名称 |
CYTOCHROME P450 SUICIDE GENE SYSTEM |
摘要 |
The invention relates to a modified human CYP4B1 protein and a nucleic acid encoding for the modified human CYP4B1 protein. The invention further relates to an expression vector comprising a nucleic acid encoding for a modified human CYP4B1 protein, as well as to a cell comprising a modified CYP4B1 protein. In addition, the invention relates to a modified human CYP4B1 protein for use in treating transplantation induced graft-versus-host-disease (GvHD), and to 4-ipomeanol (4-IPO) for use in killing a cell. |
申请公布号 |
EP2855681(A1) |
申请公布日期 |
2015.04.08 |
申请号 |
EP20130727093 |
申请日期 |
2013.05.28 |
申请人 |
HANENBERG, HELMUT |
发明人 |
WIEK, Constanze;KRAMM, Christof;SCHMIDT, Eva Maria |
分类号 |
C12N15/53;A61K48/00;C12N5/10;C12N9/02 |
主分类号 |
C12N15/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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