发明名称 |
HUMANIZED AND CHIMERIC MONOCLONAL ANTIBODIES TO CD47 |
摘要 |
Humanized or chimeric anti-CD47 monoclonal antibodies are provided. The antibodies bind to and neutralize human CD47, and find use in various therapeutic methods. Preferred are non-activating antibodies. Embodiments of the invention include isolated antibodies and derivatives and fragments thereof, pharmaceutical formulations comprising one or more of the humanized or chimeric anti-CD47 monoclonal antibodies; and cell lines that produce these monoclonal antibodies. Also provided are amino acid sequences of the antibodies. |
申请公布号 |
EP2569013(A4) |
申请公布日期 |
2015.04.08 |
申请号 |
EP20110781385 |
申请日期 |
2011.05.13 |
申请人 |
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY |
发明人 |
LIU, JIE;WEISSMAN, IRVING L.;MAJETI, RAVINDRA |
分类号 |
A61K39/395;C07K16/28;C12N5/07;C12N5/16;C12P21/08;G01N33/68 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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