发明名称 |
PHARMACEUTICAL COMPOSITION CONTAINING FIBULIN-3 PROTEIN AS AN ACTIVE INGREDIENT FOR INHIBITING THE GROWTH OF CANCER STEM CELLS |
摘要 |
The present invention relates to fibulin-3 protein and a pharmaceutical composition comprising the fibulin-3 protein as an active ingredient for inhibiting the growth of cancer stem cells. More particularly, in cancer stem cells separated from H460 and A549 cells, which are non-small-cell lung cancer cells, using ALDH1 activity as a marker, fibulin-3 induces the reductions of wnt/²-catenin, MMP2 and 7, which display characteristics of cancer stem cells, thereby decreasing the activated growth and penetration of the cancer stem cells. In addition, the purified fibulin-3 protein inhibits the growth of the non-small-cell lung cancer cell line A549, the breast cancer cell line MDA-MB231, and the cancer stem cell line active ALDH1. Therefore, fibulin-3 can be valuably used as an active ingredient of the pharmaceutical composition for inhibiting the growth of cancer stem cells. |
申请公布号 |
EP2742950(A4) |
申请公布日期 |
2015.04.08 |
申请号 |
EP20110870806 |
申请日期 |
2011.12.22 |
申请人 |
KOREA ATOMIC ENERGY RESEARCH INSTITUTE |
发明人 |
KIM, IN-GYU;SHIN, BYUNGCHUL;KIM, KUG CHAN;KIM, SEO YEON;KIM, MIN JUNG;LEE, SO YONG |
分类号 |
A61K38/39;A61K38/17;A61P35/00;C07K14/78 |
主分类号 |
A61K38/39 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|