发明名称 |
ERAP1-DERIVED PEPTIDE AND USE THEREOF |
摘要 |
Provided is a novel cancer-treating agent which can be used as a novel choice for the treatment of cancer. Specifically provided are: a peptide that inhibits binding of ERAP1 polypeptide to PHB2 polypeptide, which comprises a binding site of the ERAP1 polypeptide to the PHB2 polypeptide, and a pharmaceutical composition comprising the peptide. In addition, provided is a method for screening a drug candidate for treating and/or preventing cancer using inhibition of the binding of the ERAP1 polypeptide to PP1± polypeptide, PKA polypeptide or PKB polypeptide as an index. |
申请公布号 |
EP2738255(A4) |
申请公布日期 |
2015.04.08 |
申请号 |
EP20120820786 |
申请日期 |
2012.07.27 |
申请人 |
THE UNIVERSITY OF TOKUSHIMA;ONCOTHERAPY SCIENCE, INC. |
发明人 |
KATAGIRI, TOYOMASA;TSUNODA, TAKUYA |
分类号 |
C12N15/09;A61K38/00;A61P35/00;C07K14/47;C12Q1/68;G01N33/68 |
主分类号 |
C12N15/09 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|