SILK-BASED BIOACTIVE OLIGOPEPTIDE COMPOSITIONS AND MANUFACTURING PROCESS THEREFOR

摘要

A process for preparing or manufacturing target molecular weight silk-derived oligopeptides with bioactive properties includes providing silk cocoon, extracting proteins or peptides from the silk cocoon, introducing an enzyme solution to obtain oligopeptides, and separating target oligopeptides from other peptides. Silk-derived oligopeptides in accordance with the present disclosure possess one or more of antioxidant properties, cholesterol lowering activity, lipid oxidation prevention properties, blood sugar lowering properties, blood pressure lowering properties, natural killer cell enhancement activity, insulin production enhancement activity, body weight regulatory activity, central nervous system stimulant properties, and neuroprotective, cognitive function protective, memory protective, and/or neural function improvement properties (e.g., memory deficit alleviation, spatial memory improvement, recognition memory improvement, learning improvement, synaptic transmission facilitation, and anti -neurodegenerative properties).