发明名称 |
RECOMBINANT MICROORGANISMS AND USES THEREFOR |
摘要 |
Bacteria are genetically engineered to produce 3-hydroxypropionate (3-HP). The bacteria are carboxydotrophic acetogens. The bacteria produce acetyl-coA using the Wood-Ljungdahl pathway for fixing CO/CO2. A malonyl-coA reductase from a bacterium that contains such an enzyme is introduced. Additionally, an acetyl-coA carboxylase may also be introduced The production of 3-HP can be improved by overproduction of acetyl-CoA carboxylase or by overproduction of biotin. This can be effected by improved promoters or higher copy number or enzymes that are catalytically more efficient. |
申请公布号 |
EP2855690(A1) |
申请公布日期 |
2015.04.08 |
申请号 |
EP20130797085 |
申请日期 |
2013.05.30 |
申请人 |
LANZATECH NEW ZEALAND LIMITED |
发明人 |
CHEN, WENDY;KOEPKE, MICHAEL |
分类号 |
C12P7/62;C12N1/21;C12N15/53;C12N15/63;C12N15/74 |
主分类号 |
C12P7/62 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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