发明名称 TOPICAL DRUG DELIVERY SYSTEMS FOR OPHTHALMIC USE
摘要 <p>Topical drug delivery systems for ophthalmic use including mixed nanomicellar formulations of water-insoluble drugs and methods of treating diseases affecting the posterior ocular segments are disclosed. In an embodiment, an aqueous ophthalmic solution includes nanomicelles in a physiologically acceptable buffer, having a pH of 5.0 to 8.0, wherein a corticosteroid at a concentration from about 0.01% w/v to about 1.00% w/v is solubilized through entrapment in a mixed micellar hydrophobic core with a corona composed of hydrophilic chains extending from the hydrophobic core, wherein the nanomicelles comprise vitamin E TPGS at a concentration ranging from about 3.0% w/v to about 5.0% w/v stabilized with octoxynol-40 at a concentration ranging from about 1.0% w/v to about 3.0% w/v.</p>
申请公布号 EP2440185(B1) 申请公布日期 2015.04.08
申请号 EP20100786539 申请日期 2010.05.05
申请人 AURINIA PHARMACEUTICALS INC. 发明人 MITRA, ASHIM K.;VELAGALETI, POONAM R.;GRAU, ULRICH M.
分类号 A61K9/14;A61K9/00;A61K9/107;A61K31/14;A61K31/436;A61K31/573;A61K47/10;A61K47/22;A61P27/02 主分类号 A61K9/14
代理机构 代理人
主权项
地址