发明名称 |
METHODS FOR SELECTIVE OXIDATION OF ALPHA TOCOTRIENOL IN THE PRESENCE OF NON-ALPHA TOCOTRIENOLS |
摘要 |
A method of producing alpha-tocotrienol quinone or a stereoisomer thereof, the method comprising selective opening of alpha-tocotrienol chroman to alpha-tocotrienol quinone in the presence of non-alpha tocotrienol chromans by oxidizing alpha-tocotrienol with a metal salt oxidizing agent, wherein the stoichiometric ratio of metal salt oxidizing agent/alpha-tocotrienol is at least 4:1 and wherein said metal oxidizing agent is added in sequential additions, in order to reduce oxidation of any amounts of non-alpha tocotrienol chromans that might have been present in the starting alpha-tocotrienol chroman material. This process uses conditions favoring oxidation rates of the alpha tocotrienol chroman vs. the non-alpha tocotrienol chromans. |
申请公布号 |
EP2734512(A4) |
申请公布日期 |
2015.04.08 |
申请号 |
EP20120814970 |
申请日期 |
2012.07.19 |
申请人 |
EDISON PHARMACEUTICALS, INC. |
发明人 |
MOLLARD, PAUL |
分类号 |
C07D311/72;C07C46/06;C07C50/28 |
主分类号 |
C07D311/72 |
代理机构 |
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代理人 |
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地址 |
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