| 发明名称 | Chimeric adenoviral vectors | ||
| 摘要 | The present invention provides chimeric adenoviral vectors and methods for using the vectors to elicit an immune response to an antigen of interest. | ||
| 申请公布号 | US8999946(B2) | 申请公布日期 | 2015.04.07 |
| 申请号 | US201213532701 | 申请日期 | 2012.06.25 |
| 申请人 | Vaxart, Inc. | 发明人 | Tucker Sean N. |
| 分类号 | A61K48/00;C12N15/861;A61K39/39;A61K39/145;A61K39/21;C07H21/02;C12N15/86;A61K39/00 | 主分类号 | A61K48/00 |
| 代理机构 | Kilpatrick Townsend & Stockton LLP | 代理人 | Kilpatrick Townsend & Stockton LLP |
| 主权项 | 1. An immunogenic composition, said composition comprising: (a) a chimeric adenoviral expression vector comprising a promoter operably linked to a nucleic acid encoding a heterologous polypeptide, wherein the heterologous polypeptide is an human papilloma virus (HPV) polypeptide or herpes simplex virus (HSV) polypeptide; (b) a non-specific immune response enhancer selected from dsRNA and a dsRNA mimetic; and (c) a pharmaceutically acceptable carrier. | ||
| 地址 | South San Francisco CA US | ||