PKC ligands and polynucleotides encoding PKC ligands

摘要

The invention relates to kinase ligands and polyligands. In particular, the invention relates to ligands, homopolyligands, and heteropolyligands that modulate PKC activity. The ligands and polyligands are utilized as research tools or as therapeutics. The invention includes linkage of the ligands, homopolyligands, and heteropolyligands to a cellular localization signal, epitope tag and/or a reporter. The invention also includes polynucleotides encoding the ligands and polyligands.

主权项

1. An isolated polynucleotide comprising a nucleotide sequence encoding a polypeptide polyligand comprising monomeric ligands, said polypeptide polyligand having at least 95% sequence identity to the polypeptide of SEQ ID NO: 5, wherein said polypeptide polyligand inhibits protein kinase C activity.