摘要 |
<p>A compound of Formula I is set forth, including pharmaceutically acceptable salts thereof: wherein Het is a 5 or 6-membered heterocycle with—N,—O, or—S adjacent to the—Ar substituent or adjacent to the point of attachment for the—Ar substituent; Ar is aryl or heteroaryl; R is—CH3,—CH2F, or—CH═CH2; W is—NO2,—Cl,—Br,—CHO,—CH═CH2, or—CN; X is—Cl,—CH3, or—CN; Y is—CH or—N; and Z is C1-C6 alkyl, C3-C6 cycloalkyl, substituted aryl, substituted heteroaryl, OR1, or NHR1, wherein R1 is selected from the group of H, aryl, heteroaryl, C1-C6 alkyl and C3-C6 cycloalkyl. This compound is useful in compositions for the prevention and treatment of influenza virus.</p> |
申请人 |
BRISTOL-MYERS SQUIBB COMPANY |
发明人 |
CIANCI, CHRISTOPHER;GERRITZ, SAMUEL;LI, GUO;PEARCE, BRADLEY;PENDRI, ANNAPURNA;SHI, SHUHAO;ZHAI, WEIXU;ZHU, SHIRONG |