Increase of myeloid microvesicles in the cerebrospinal fluid as biomarker of microglia/macrophage activation in neurological disorders

摘要

The present invention relates to a method for the diagnostic and/or prognostic of a neurological disease characterized by an inflammation process in a subject comprising measuring the amount of myeloid derived microvesicles in a cerebrospinal fluid sample obtained from the subject. The invention further relates to a method for predicting and/or monitoring the efficacy of a treatment for a neurological pathology or for monitoring a neurological disease progression.

主权项

1. A method for diagnosing and/or monitoring of a neurological disease characterized by an inflammatory process wherein the neurological disease and/or the inflammatory process is characterized by microglial activation in a subject, the method comprising
(a) labeling microglia/macrophage derived microvesicles with IB-4, wherein the microvesicles are present in a cerebrospinal fluid sample obtained from the subject; (b) measuring the amount of said labelled myeloid microglia/macrophage derived microvesicles in said sample obtained from the subject,wherein if the measured amount is above a control value, the subject is affected by a neurological disease characterized by an inflammatory process.