发明名称 |
Self-emulsifying pharmaceutical compositions of rhein or diacerein |
摘要 |
The invention relates to self emulsifying drug delivery system based compositions of rhein or diacerein, or salts or esters or prodrugs thereof which are bioequivalent to a 50 mg diacerein formulation marketed under the trade name Art 50®. The compositions exhibit no variability in fed and fasted state conditions. The compositions also result in significant reduction in side effects such as, soft stools effects as compared to Art 50®. The invention also relates to methods for preparing such compositions. |
申请公布号 |
US8999381(B2) |
申请公布日期 |
2015.04.07 |
申请号 |
US200812680335 |
申请日期 |
2008.09.27 |
申请人 |
Wockhardt Ltd. |
发明人 |
Nakhat Premchand;Mandaogade Prashant;Jain Girish Kumar;Talwar Munish |
分类号 |
A61K9/14;A61K9/48;A61K9/107;A61K31/222;A61K47/44 |
主分类号 |
A61K9/14 |
代理机构 |
Bio Intellectual Property Services LLC (Bio IPS) |
代理人 |
Bio Intellectual Property Services LLC (Bio IPS) ;Zoghmout O. (Sam) |
主权项 |
1. A pharmaceutical composition comprising from about 10-90% w/w of diacerein, about 1-70% w/w of Labrafil, about 10-90% w/w of polyoxyethylene glycerol esters of fatty acid, about 5-70% w/w of PEG-40 hydrogenated castor oil, about 5-60% w/w of Lauroyl polyoxylglycerides and about 2-50% w/w of HPC. |
地址 |
Bandra East, Mumbai IN |