发明名称 |
Composition that can be cured by polymerisation for the production of biodegradable, biocompatible, cross-linkable polymers on the basis of polyvinyl alcohol |
摘要 |
The present invention relates to a polymerization-curable composition for the preparation of biodegradable, biocompatible, cross-linked polymers on the basis of polyvinyl alcohol comprising: 5 to 100% by weight of (a) vinyl ester monomer(s) of one of the general formulas (I) to (III):;
wherein X is oxygen, sulfur, nitrogen, or phosphorus; n is 1 to 1000, at least 20% of the n being ≧2; the R1 are selected from hydrogen; straight, branched or cyclic, saturated or unsaturated, n-valent hydrocarbon groups having 1 to 30 carbon atoms, which optionally have heteroatoms and are optionally substituted with one or more substituents selected from —OH, —COON, —CN, —CHO, and ═O, and n-valent radicals of biodegradable, biocompatible oligomers and polymers; m is an integer from 1 to 5; the R2 are selected from hydrogen, —OH, ═O, and the options listed for R1; and the R3 are selected from hydrogen, —OH, and the options listed for R1; 0 to 50% by weight of ethylenically unsaturated co-monomers; 0 to 10% by weight of (a) polymerization initiator(s); and 0 to 95% by weight of solvent(s). |
申请公布号 |
US8999323(B2) |
申请公布日期 |
2015.04.07 |
申请号 |
US200812744412 |
申请日期 |
2008.11.21 |
申请人 |
Technische Universität Wien |
发明人 |
Liska Robert;Stampfl Jürgen;Varga Franz;Gruber Heinrich;Baudis Stefan;Heller Christian;Schuster Monika;Bergmeister Helga;Weigel Günter;Dworak Claudia |
分类号 |
A61K39/395;A61K38/16;C07C271/10;C07C271/20;C07C271/22;C07C69/96;C07F9/113;C07F9/40;C08F2/46;A61L27/56 |
主分类号 |
A61K39/395 |
代理机构 |
Drinker Biddle & Reath LLP |
代理人 |
Drinker Biddle & Reath LLP |
主权项 |
1. A method for preparing a body implant comprising a biodegradable, biocompatible, cross-linked polymer, which method comprises the following steps:
providing a polymerization-curable composition comprising:
(a) 5 to 100% by weight of one or more vinyl ester monomers of the general formula (II): wherein:
X is a heteroatom selected from the group consisting of oxygen, sulfur, nitrogen, and phosphorus;n is 1 to 1000, at least 20% of the n being ≧2;the groups R1 are independently selected from:
(i) hydrogen; straight, branched or cyclic, saturated or unsaturated, n-valent hydrocarbon groups which have 1 to 30 carbon atoms, which optionally comprise one or more heteroatoms selected from oxygen, sulfur, nitrogen, and phosphorus within the carbon chains and/or at the end of the carbon chains thereof, and which are optionally substituted with one or more substituents selected from the group consisting of —OH, —COOH, —CN, —CHO), and ═O, and(ii) n-valent radicals of biodegradable, biocompatible oligomers and polymers selected from the group consisting of polysaccharides, polypeptides, polyamides, polyesters, polycarbonates, polyethers, and fatty acid derivatives;m is an integer from 0 to 4; andthe groups R2 are selected from the group consisting of —OH, ═O, andthe options listed for R1;(b) 0 to 50% by weight of one or more a-olefin co-monomers;(c) 0 to 10% by weight of one or more polymerization initiators selected from the group consisting of thermal initiators and photoinitiators; and(d) 0 to 95% by weight of one or more solvents selected from the group consisting of water, lower alcohols, ether, ketone, ester, amide and hydrocarbon solvents; shaping the composition; and thermally or photochernically polymerizing and thus curing the shaped composition to provide the body implant. |
地址 |
Schleinbach AT |