发明名称 |
Hydrazide containing nuclear transport modulators and uses thereof |
摘要 |
The invention generally relates to nuclear transport modulators, e.g., CRM1 inhibitors, and more particularly to a compound represented by structural formula I:;
or a pharmaceutically acceptable salt thereof, wherein the values and alternative values for the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of structural formula I, or a pharmaceutically acceptable salt or composition thereof, e.g., in the treatment, modulation and/or prevention of physiological conditions associated with CRM1 activity. |
申请公布号 |
US8999996(B2) |
申请公布日期 |
2015.04.07 |
申请号 |
US201414219638 |
申请日期 |
2014.03.19 |
申请人 |
Karyopharm Therapeutics Inc. |
发明人 |
Sandanayaka Vincent P.;Shacham Sharon;McCauley Dilara;Shechter Sharon |
分类号 |
A61K31/497;C07D241/20;C07D403/12;C07D401/12;C07D409/12;C07D249/08 |
主分类号 |
A61K31/497 |
代理机构 |
Hamilton, Brook, Smith & Reynolds, P.C. |
代理人 |
Hamilton, Brook, Smith & Reynolds, P.C. |
主权项 |
1. A compound represented by the following structural formula: or a pharmaceutically acceptable salt thereof. |
地址 |
Newton MA US |