| 摘要 |
The invention relates to kinase inhibitors of the formula (I) in which —R1 to R4═H; ether or polyether, amino; NO2; NH-carbamate; NH—CO—R, with R such as defined above; N3 and derivatives thereof of the 1,2,3-triazole type; —R5=—OH; halogen; —OR with R such as defined above; OH-carbamate; OH-carbonate; NH2, NH-carbamate; NH—CO—R, with R such as defined above; N3 and derivatives thereof of the 1,2,3-triazole type; N(R9,R10); —R5′═H or a C1-C12 alkyl, —R6═H; R; (R or R′)3—Si, with R such as defined above; optionally substituted aryl, heteroaryl; halogen (iodine); alkynyl; —R7 and R8═H, C1-C12 alkyl; —R9 and R10═H, R (or R′) such as defined above. These compounds can be used as kinase inhibitors in particular for treating cancer. |
| 主权项 |
1. A kinase inhibitor compound of formula (I) in which:
R1 to R4, which may be identical or different, represent H; an ether radical —OR, wherein R represents a linear or branched C1-C12 alkyl radical; an amino group NH2 or N(R9, R10); NO2; NH-carbamate of —NH—CO-OM type, with M representing R or a salt; NH—CO—R; N3 or derivatives thereof with a 1,2,3-triazole cycle;R5 represents an —OH group; halogen; —OR with R as defined above with respect to R1-R4; OH-carbamate of —O—CO—NHM type, with M representing R, as defined above with respect to R1-R4; OH-carbonate of —O—CO-OM type, with M representing R, as defined above with respect to R1-R4; NH2, NH-carbamate of —NH—CO-OM type, with M representing R, or a salt; NH—CO—R with R as defined above with respect to R1-R4; N3 or derivatives thereof with a 1,2,3-triazole cycle; or N(R9, R10);R5′ represents H or a C1-C12 alkyl radical,or R5/R5′ together represents an ═O group;R6 represents H; the R radical; an (R or R′)3—Si group, R being as defined above with respect to R1-R4; an aryl radical, where appropriate substituted, a heteroaryl radical; a halogen; or an alkynyl radical —C≡C—R;R7 and R8, which may be identical or different, represent an H or a C1-C12 alkyl radical;R9 and R10, which may be identical or different, represent H or the R-radical, with the exception of the compounds in which R1-R4, R7 and R8═H, R5 and R5′ form a —C═O group, and R6═—(CH3)3—Si, —C6H5, or C1 or C4 alkyl; R1-R4, R7 and R8═H, R5═OH and R5′═H, and R6=—(CH3)3—Si, —C6H5, or C1 or C4 alkyl; R1-R4, R7 and R8═H, R5═H and R5′═OH, and R6=—(CH3)3—Si, —C6H5, or C1 or C4 alkyl; R1-R4, R7 and R8═H, R5=—OCH3 and R5′═H, and R6═C4 alkyl; and R1-R4, R7 and R8═H, R5═H and R5′=—OCH3, and R6═C4 alkyl. |
