Methods for treating multiorgan, systemic degos' disease with a complement inhibitor

摘要

The present disclosure relates to, inter alia, compositions containing an inhibitor of human complement and/or an inhibitor of interferon alpha, and the use of the compositions in methods for treating or preventing Degos' disease in a subject. In some embodiments, the inhibitor is an antibody, or antigen-binding fragment thereof, that binds to a human complement component C5 protein or to a biologically-active fragment of C5 such as C5a or C5b. In some embodiments, the inhibitor is an antibody, or an antigen-binding fragment thereof, that binds to interferon alpha or to an interferon alpha receptor.

主权项

1. A method for treating a patient afflicted with Degos' disease, the method comprising administering an antibody, or antigen-binding fragment thereof, that binds to a human complement component C5 protein, to a patient afflicted with Degos' disease, in an amount sufficient to treat the disease or lessen the severity of one or more symptoms of the disease, wherein the Degos' disease is multiorgan, systemic Degos' disease and wherein the one or more symptoms is selected from the group consisting of skin lesions, gastrointestinal bleeding, vomiting, enterocutaneous fistula, facial and acral paraesthesia, headaches, dizziness, aphagia, paraplegia, gaze palsy, epilepsy, memory loss, altered sensation, strokes, diplopia, ptosis, visual-field defects, weakness, shortness of breath, and chest pain.