TGR5 modulators and methods of use thereof

摘要

The invention relates to compounds of Formula (A): (A) or a salt, solvate, hydrate, or amino acid conjugate thereof. The compounds of formula A are TGR5 modulators useful for the prevention and treatment of disease.;

主权项

1. A compound of formula A: or a salt, solvate, hydrate, or amino acid conjugate thereof, wherein:
R1 is hydrogen, hydroxyl, substituted or unsubstituted alkyl, or halogen;R2 is hydrogen or hydroxyl;R4 is substituted or unsubstituted alkyl or halogen;R7 is hydrogen, substituted or unsubstituted alkyl, or hydroxyl;R11 is hydroxyl, OSO3H, OSO3−, OCOCH3, OPO3H, OPO32−, OC6H8O6−, or hydrogen;R12 is hydroxyl, OSO3H, OSO3−, OCOCH3, OPO3H, OPO32−, OC6H8O6−, or hydrogen, or taken together R11 and R12 form a carbonyl; andR16 is hydroxyl, alkoxy, or halogen.