发明名称 |
Polypeptides and antibodies derived from chronic lymphocytic Leukemia cells and uses thereof |
摘要 |
Small animal models for assessing immunomodulatory effects of compounds are provided. |
申请公布号 |
US8999328(B2) |
申请公布日期 |
2015.04.07 |
申请号 |
US201113072470 |
申请日期 |
2011.03.25 |
申请人 |
Alexion Pharmaceuticals, Inc. |
发明人 |
Bowdish Katherine S.;Kretz-Rommel Anke |
分类号 |
A61K39/00;G01N33/574;A61K47/48;C07K16/28;C07K16/30 |
主分类号 |
A61K39/00 |
代理机构 |
Nelson Mullins Riley & Scarborough LLP |
代理人 |
Nelson Mullins Riley & Scarborough LLP ;Remillard, Esq. Jane E.;Frank Christopher L. |
主权项 |
1. A method for treating chronic lymphocytic leukemia (CLL), said method comprising administering to a patient suffering from CLL an antibody, or an antigen-binding fragment thereof, that binds to OX-2/CD200 and comprises a light chain CDR1 having the sequence set forth in residues 26-36 of SEQ ID NO:209; a light chain CDR2 having the sequence set forth in residues 52-58 of SEQ ID NO:209; a light chain CDR3 having the sequence set forth in residues 91-99 of SEQ ID NO:209; a heavy chain CDR1 having the sequence set forth in SEQ ID NO:149; a heavy chain CDR2 having the sequence set forth in SEQ ID NO:174; and a heavy chain CDR3 having the sequence set forth in SEQ ID NO:195, wherein the patient's CLL has been identified as overexpressing OX-2/CD200 three to six-fold as compared to normal peripheral blood mononuclear cells. |
地址 |
Cheshire CT US |