Electrical therapy for diastolic dysfunction

摘要

Pacing pulses are delivered to one or more cardiac regions to improve diastolic performance in patients having diastolic dysfunction and/or heart failure. A cardiac pacing system executes a pacing algorithm using a parameter indicative of the diastolic performance as an input. The pacing pulses excite the one or more cardiac regions to redistribute the loading on the ventricular wall during diastole, thereby improving the diastolic performance by lowering the degree of cardiac wall motion dyssynchrony associated with diastolic dysfunction.

主权项

1. A method, comprising:
predicting an effectiveness of delivering pacing pulses to improve a measure of diastolic performance, wherein predicting the effectiveness includes:
recording a left ventricular echocardiogram;dividing a left ventricular endocardial wall into multiple regions;measuring left ventricular regional endocardial wall displacements over at least one cardiac cycle for each of the regions using the recorded left ventricular echocardiogram; andpredicting the effectiveness if the left ventricular regional endocardial wall displacements are significantly non-uniform across the left ventricular endocardial wall; and delivering the pacing pulses to one or more cardiac regions to improve the diastolic performance in response to the effectiveness being predicted.