| 发明名称 | Cyclic triazo sodium channel blockers | ||
| 摘要 | The present invention relates to triazine compounds having sodium channel blocking properties, and to use of the compounds for preparation of medicaments for treatment of associated disorders. The compounds are of formula I:;in which R1 is a halo-alkyl group and A is an optionally substituted aromatic heterocyclic or carbocyclic ring system,or a pharmaceutically acceptable salt or solvate thereof. | ||
| 申请公布号 | US9000155(B2) | 申请公布日期 | 2015.04.07 |
| 申请号 | US201414266398 | 申请日期 | 2014.04.30 |
| 申请人 | University Of Greenwich | 发明人 | Leach Michael;Franzmann Karl;Riddall Dieter;Harbige Laurence |
| 分类号 | C07D253/07;A61K31/53;A61P25/08;A61P25/28;A61P25/04;C07D253/075;C07D409/04;C07D309/04;C07D309/06;C07D309/08 | 主分类号 | C07D253/07 |
| 代理机构 | Cesari and McKenna, LLP | 代理人 | Cesari and McKenna, LLP |
| 主权项 | 1. A compound according to formula (I): or a pharmaceutically acceptable salt or solvate thereof, whereini) A is 2,3-dichlorophenyl and R1 is —CH2CCl3, —CH2CF2CF3, or —CH2CF2CHF2;ii) A is 2,3,5-trichlorophenyl and R1 is —CH2CCl3, —CH2CHCl2, or CH2CBr3;iii) A is 3,5,-bistrifluoromethylphenyl and R1 is —CH2CCl3, —CH2CHCl2, or CH2CBr3;iv) A is bisphenyl methyl and R1 is —CH2CCl3, —CH2CHCl2, or CH2CBr3; orv) A is 2-(3,4,5)-trichloro-bis-phenyl and R1 is —CH2CCl3, —CH2CHCl2, or CH2CBr3. | ||
| 地址 | London Greater London GB | ||