Mixture and method for reducing cholesterol using hydrophobic microparticles

摘要

The present invention relates to mixtures including hydrophobic microparticles comprising a positively charged polymer (e.g. a polysaccharide such as chitosan) non-covalently bound to an anionic or non-ionic surfactant such as lecithin. The mixtures are useful for reducing cholesterol of an animal, for example a bird such as a chicken or any type of mammal. Methods of manufacture and use of the mixtures are also disclosed herein.

主权项

1. A mixture useful for cholesterol treatment, the mixture comprising a plurality of hydrophobic composite particles, each said composite particle consisting of achitosan and lecithin, said chitosan is non-covalently bound to a lecithin by at least hydrophobic interactions, wherein
said composite particles having a lecithin-chitosan mass ratio of between 3:1 and 5:1, and wherein when the hydrophobic composite particles are introduced into a medium having a pH of about 6.8: (i) said hydrophobic composite particles remain as stable particle suspension in the medium; (ii) said hydrophobic stable composite particles agglomerate with bile salts in said medium and precipitate together with said bile salts.