| 发明名称 | Thioredoxin interacting protein (TXNIP) as regulator of vascular function | ||
| 摘要 | The present invention relates to screening assays for the identification of agents that can modify the interaction of thioredoxin interacting protein (TXNEP) on thioredoxin (TRX)5 preferably by inhibiting TXNIP downregulation of TXR. The use of such compounds, including the disclosed siRNA and antibodies against TXNIP, is contemplated for therapeutic or prophylactic treatment of vascular disease conditions, particularly those associated with pro-inflammatory activity of the TNF-ASK1-JNK-p38 pathways. | ||
| 申请公布号 | US8999944(B2) | 申请公布日期 | 2015.04.07 |
| 申请号 | US200611814442 | 申请日期 | 2006.01.20 |
| 申请人 | University of Rochester | 发明人 | Berk Bradford C. |
| 分类号 | A61K48/00;C07H21/02;C07H21/04;G01N33/68 | 主分类号 | A61K48/00 |
| 代理机构 | LeClairRyan, a Professional Corporation | 代理人 | LeClairRyan, a Professional Corporation |
| 主权项 | 1. A method of treating a vascular disease characterized by reduced laminar flow in a subject comprising: selecting a subject having a vascular disease characterized by reduced laminar flow; and administering to the selected subject a therapeutically effective amount of a nucleic acid molecule that inhibits expression of thioredoxin interacting protein (TXNIP) under conditions effective to inhibit expression of TXNIP in endothelial or vascular smooth muscle cells, thereby treating the vascular disease characterized by reduced laminar flow. | ||
| 地址 | Rochester NY US | ||