发明名称 |
Therapeutic agents for reducing parathyroid hormone levels |
摘要 |
Compounds having activity for lowering parathyroid hormone levels are described. In one embodiment, the compounds are comprised of a contiguous sequence of subunits, X1-X2-X3-X4-X5-X6-X7, wherein the X1 subunit comprises a thiol-containing moiety and the distribution of charge on the X2-X7 subunits provides the desired activity. Methods of using the compounds for treating hyperparathyroidism, bone disease and/or hypercalcemic disorders are also described, and in particular, methods for lowering plasma PTH and serum calcium are provided. The compounds can be used to treat subjects having, for example: primary, secondary or tertiary hyperparathyroidism; hypercalcemia of malignancy; metastatic bone disease; or osteoporosis. |
申请公布号 |
US8999932(B2) |
申请公布日期 |
2015.04.07 |
申请号 |
US201012846724 |
申请日期 |
2010.07.29 |
申请人 |
KAI Pharmaceuticals, Inc. |
发明人 |
Karim Felix;Baruch Amos;Maclean Derek;Das Kanad;Yin Qun |
分类号 |
A61K38/08;A61P13/12;A61P5/18;C07K7/06;C07K7/08;A61K47/48;C07K5/103;A61K38/00 |
主分类号 |
A61K38/08 |
代理机构 |
McDermott Will & Emery LLP |
代理人 |
McDermott Will & Emery LLP |
主权项 |
1. A conjugate, comprising a peptide and a conjugating group, wherein the peptide comprises the amino acid sequence carrrar (SEQ ID NO:2), and wherein the peptide is linked to the conjugating group by a disulfide bond. |
地址 |
South San Francisco CA US |