| 发明名称 | Process for the preparation of anhydrous aripiprazole crystal form II | ||
| 摘要 | The present invention relates to a process for preparation of aripiprazole crystal form II by recrystallizing aripiprazole in a mixture of acetone and 1-methoxy-2-propanol or a single solvent of 1-methoxy-2-propanol. The simple process according to the present invention can produce aripiprazole crystal form II with high purity and high yield in a mass scale. | ||
| 申请公布号 | US9000165(B2) | 申请公布日期 | 2015.04.07 |
| 申请号 | US201214008167 | 申请日期 | 2012.03.30 |
| 申请人 | Daewoong Pharmaceutical Co., Ltd. | 发明人 | Choi Soo Jin;Oh Seong Soo;Jin Yong Suk;Kim Yong Tae;Lee Seung Jae;Son Jeong Hyun |
| 分类号 | C07D401/06;C07D215/227;A61K31/4709;A61K31/496 | 主分类号 | C07D401/06 |
| 代理机构 | Seed IP Law Group PLLC | 代理人 | Seed IP Law Group PLLC |
| 主权项 | 1. A process for preparation of anhydrous aripiprazole crystal form II, which comprises the following steps: a) introducing aripiprazole crystal form III into a mixed solvent of acetone and 1-methoxy-2-propanol or a single solvent of 1-methoxy-2-propanol; b) dissolving aripiprazole crystal form III with heating and stirring; c) seeding a crystal of aripiprazole crystal form II; and d) isolating the desired aripiprazole crystal form II from the solution. | ||
| 地址 | Seongnam-si KR | ||