1,3,4-Oxadiazoles-2-thio derivatives as sphingosine-1 phosphate receptors modulators

摘要

The present invention relates to substituted 1,3,4-oxadiazoles-2-thio derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of sphingosine-1-phosphate receptors.

主权项

1. A compound having Formula I, its enantiomers, diastereoisomers, tautomers or a pharmaceutically acceptable salt thereof, wherein: X is S, SO or SO2; R1 is hydrogen, halogen, substituted or unsubstituted C1-6 alkyl, NO2, CN, C(O)R13 or hydroxyl; R2 is hydrogen, halogen, substituted or unsubstituted C1-6 alkyl, NO2, CN, C(O)R13 or hydroxyl; R3 is hydrogen, halogen, substituted or unsubstituted C1-6 alkyl, NO2, CN, C(O)R13 or hydroxyl; R4 is hydrogen, halogen, substituted or unsubstituted C1-6 alkyl, NO2, CN, C(O)R13 or hydroxyl; R5 is hydrogen, halogen, substituted or unsubstituted C1-6 alkyl, NO2, CN, C(O)R13 or hydroxyl; R6 is H or C1-6 alkyl; R7 is hydrogen, halogen, substituted or unsubstituted C1-6 alkyl, NO2, CN, C(O)R13 or hydroxyl; R8 is CH, S, O, N, NH or CH2; R9 is CH or CH2; R10 is hydrogen, halogen, substituted or unsubstituted C1-3 alkyl, NO2, CN, C(O)R13 or hydroxyl; R11 is H or C1-3 alkyl; R12 is OPO3H2, carboxylic acid, PO3H2, —P(O)MeOH, —P(O)(H)OH or OR14; a is 0 or 1; b is 1, 2 or 3; R13 is OH or C1-3 alkyl; R14 is H or C1-3 alkyl; when a is 1 then and when a is 0 then and R8 is S, O, NH or CH2.