NOVEL FORMS OF CO-CRYSTALS OF AGOMELATINE AND P-TOLUENESULPHONIC ACID, METHOD FOR PREPARING SAME AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING SAME

摘要

The present invention concerns novel forms of co-crystals of agomelatine and p-toluenesulphonic acid, the method for preparing same and the pharmaceutical compositions containing same. The co-crystals according to the invention have better solubility than agomelatine and are therefore more suitable for developing pharmaceutical compositions. They have a higher level of stability and purity, and are moreover obtained by a simple method that comprises no difficult steps.