| 发明名称 |
INHIBITORS OF THE FARNESOID X RECEPTOR AND USES IN MEDICINE |
| 摘要 |
Disclosed are inhibitors of the farnesoid X receptor, for example of formula (I), wherein R1, R2, R4, X, Y, Z, m, and n are as defined herein, which are useful in treating or preventing obesity, type 2 diabetes/insulin resistance and non alcoholic fatty liver disease in a mammal in need thereof. Also disclosed is a composition comprising a pharmaceutically suitable carrier and at least one compound of the invention, a method of method of inhibiting a farnesoid X receptor in a mammal, and a method of treating or preventing obesity in a mammal. |
| 申请公布号 |
WO2015017813(A3) |
申请公布日期 |
2015.04.02 |
| 申请号 |
WO2014US49460 |
申请日期 |
2014.08.01 |
| 申请人 |
THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES;THE PENN STATE RESEARCH FOUNDATION |
发明人 |
GONZALEZ, FRANK J.;JIANG, CHANGTAO;XIE, CEN;PATTERSON, ANDREW D.;LI, FEI;MITCHELL, JAMES B.;AMIN, SHANTU;DESAI, DHIMANT |
| 分类号 |
C07J9/00;A61K31/575;A61P1/16;A61P3/04;A61P3/10;C07J41/00 |
主分类号 |
C07J9/00 |
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