主权项 |
1. A compound of Formula (I),or a pharmaceutically acceptable salt thereof, wherein:
X is a heteroatom; R1 is hydrogen, alkyl, alkenyl, arylalkyl, alkylarylalkyl, alkoxyalkyl, heteroalkyl, or heterocyclylalkyl; R2 and R3 can be the same or different and are hydrogen, alkyl, alkenyl, cycloalkyl, alkylaryl, alkylcarbonyl, aryl, arylalkyl, alkylarylalkyl, alkoxy, alkoxyalkyl, alkoxycarbonyl, heteroalkyl, heterocyclyl, heterocyclylalkyl, or carbonyl; and R4 is alkyl, alkenyl, cycloalkyl, alkylaryl, alkylcarbonyl, aryl, arylalkyl, alkylarylalkyl, alkoxy, alkoxyalkyl, alkoxycarbonyl, heteroalkyl, heterocyclyl, or heterocyclylalkyl, wherein each R1, R2, R3, and R4 is unsubstituted or substituted with one or more of the following: alkyl, alkenyl, cycloalkyl, alkylaryl, alkylcarbonyl, aryl, arylalkyl, alkylarylalkyl, alkoxy, alkoxyalkyl, alkoxycarbonyl, heteroalkyl, heterocyclyl, or heterocyclylalkyl, —NR19R20, —SH, —S(Pg), —OH, —PR19R20, —P(O)R21R22, —CO2H, ═O, halo, trifluoromethyl, cyano, —CO2R24, —C(═O)R24, —C(═O)N(R24)2, —CHO, —CH2OR24, —OC(═O)R24, —OC(═O)OR24, —OR24, —OC(═O)N(R24)2, —NR24C(═O)R24, —NR24C(═O)OR24, —NR24C(═O)N(R24)2, —NR24SO2N(R24)2, —NR24SO2R24, —SO3H, —SO2R24, —SR24, —S(═O)R24, —SO2N(R24)2, —N(R24)2, —NHC(═S)NHR24, ═NOR24, NO2, —C(═O)NHOR24, —C(═O)NHNR24R24, —OCH2CO2H, 2-(1-morpholino)ethoxy, or a chelator moiety; R19 and R20 are each independently selected from hydrogen, C1-10alkyl substituted with 0-3 R23, aryl substituted with 0-3 R23, C3-10cycloalkyl substituted with 0-3 R23, heterocyclyl-C1-10alkyl substituted with 0-3 R23, C6-10aryl-C1-10alkyl substituted with 0-3 R23, and heterocyclyl substituted with 0-3 R23. R21 and R22 are each independently selected from —OH, C1-10alkyl substituted with 0-3 R23, aryl substituted with 0-3 R23, C3-10cycloalkyl substituted with 0-3 R23, heterocyclyl-C1-10alkyl substituted with 0-3 R23, C6-10aryl-C1-10alkyl substituted with 0-3 R23, and heterocyclyl substituted with 0-3 R23; each R23 is independently selected from ═O, halo, trifluoromethyl, cyano, —CO2R24, —C(═O)R24, —C(═O)N(R24)2, —CHO, —CH2OR24, —OC(═O)R24, —OC(═O)OR24, —OR24, —OC(═O)N(R24)2, —NR24C(═O)R24, —NR24C(═O)OR24, —NR24C(═O)N(R24)2, —NR24SO2N(R24)2, —NR24SO2R24, —SO3H, —SO2R24, —SR24, —S(═O)R24, —SO2N(R24)2, —N(R24)2, —NHC(═S)NHR24, ═NOR24, —NO2, —C(═O)NHOR24, —C(═O)NHNR24R24, —OCH2CO2H, 2-(1-morpholino)ethoxy, C1-5alkyl, C2-4alkenyl, C3-6cycloalkyl, C3-6cycloalkylmethyl, C2-6alkoxyalkyl, aryl substituted with 0-2 R24, and heterocyclyl; each R24 is independently selected from hydrogen, alkyl, alkenyl, cycloalkyl, alkylaryl, alkylcarbonyl, aryl, arylalkyl, alkylarylalkyl, alkoxy, alkoxyalkyl, alkoxycarbonyl, heteroalkyl, heterocyclyl, heterocyclylalkyl, or carbonyl; Pg is a thiol protecting group; and n′ is an integer from 0-3, wherein the compound comprises at least one chelator moiety. |