发明名称 |
ANTI-CXCR1 COMPOSITIONS AND METHODS |
摘要 |
The present invention provides methods of treating cancer by administering an IL8-CXCR1 pathway inhibitor (e.g., an anti-CXCR1 antibody or Repertaxin) alone or in combination with an additional chemotherapeutic agent such that non-tumorigenic and tumorigenic cancer cells in a subject are killed. The present invention also provides compositions and methods for detecting the presence of and isolating solid tumor stem cells in a patient (e.g., based on the presence of CXCR1 or FBXO21). |
申请公布号 |
US2015094362(A1) |
申请公布日期 |
2015.04.02 |
申请号 |
US201414566436 |
申请日期 |
2014.12.10 |
申请人 |
The Regents of The University of Michigan |
发明人 |
Wicha Max S.;Ginestier Christophe |
分类号 |
A61K31/18;A61K45/06;A61K31/337 |
主分类号 |
A61K31/18 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
Ann Arbor MI US |