METHODS OF DIAGNOSING, GRADING, MONITORING, AND TREATING HEPATIC ENCEPHALOPATHY

摘要

The present disclosure provides methods, systems, and instruments for the determination by a physician or medical professional whether a subject is experiencing or has recently experienced an overt HE episode and for grading overt HE episodes as well as methods, systems, instruments and tools for screening for overt HE episodes by a non-medical professional such as a caregiver. Also provided are methods of treating HE episodes and methods of monitoring HE episode treatment that incorporate these methods, systems, instruments, and tools.

主权项

1. A method of determining whether a subject is experiencing an overt HE episode comprising:
(a) determining whether the subject has been disoriented as to time, place, or person for at least one hour; (b) determining whether the subject has been lethargic for at least one hour and is exhibiting asterixis; and/or (c) determining that the subject is incapable of being assessed due to disorientation as to time, place, and person, somnolence, or coma, wherein the subject is classified as experiencing an overt HE episode if they meet any one of the criteria set forth in (a), (b), or (c).