BUFFERED OPHTHALMIC COMPOSITIONS AND METHODS OF USE THEREOF

摘要

The present disclosure provides a buffered ophthalmic composition for formulation of topically administrable suspensions useful for treating eye disorders by promoting wound healing, delivery of pharmaceutically active agents, and lubricating the eye. In particular the ophthalmic composition includes a buffer solution compatible with application to a mammalian eye, wherein the buffer provides increased mechanism of action of pharmaceutically active agents as well as therapeutic qualities. The ophthalmic composition exhibits dual therapeutic action to alleviate various eye disorders as it concomitantly treats corneal ulcerations and excessive inflammation which results from various eye injuries.

主权项

1. A method of accelerating or promoting healing of damaged ocular tissue or an ocular wound in a subject, comprising administering an ophthalmic composition to an eye of a subject, wherein the ophthalmic composition comprises PKC-α inhibitor, a PKC-δ activator or any combination thereof.