发明名称 |
METHOD FOR PRODUCING POLYPEPTIDE HETEROMULTIMER |
摘要 |
Provided is a method for producing a heteromultimer efficiently and stably by incubating under reducing conditions multiple types of homopolypeptides having a modification in the amino acids that form the interface of the Fc region and/or a modification to destabilize the stability of the heavy chain CH3 region introduced into the heavy chain CH3 region to achieve promotion of dissociation and/or control of association of the Fc region by utilizing charge repulsion. |
申请公布号 |
CA2925256(A1) |
申请公布日期 |
2015.04.02 |
申请号 |
CA20142925256 |
申请日期 |
2014.09.26 |
申请人 |
CHUGAI SEIYAKU KABUSHIKI KAISHA |
发明人 |
IGAWA, TOMOYUKI;KATADA, HITOSHI;MIMOTO, FUTA |
分类号 |
C07K16/00;A61K39/395;A61P35/00;C12N15/09 |
主分类号 |
C07K16/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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