BLOOD COMPATIBLE SURFACES

摘要

The disclosure features blood compatible articles and methods of making the articles. The methods include providing a substrate and forming a rough surface on the substrate. The rough surface includes a plurality of three-dimensionally curved features each having a radius of curvature of less than about 50 nm. The surface includes a sufficient concentration of features per unit area to limit blood coagulation activity on the substrate and to limit the number of platelets that adhere to the surface when the substrate is exposed to blood.

主权项

1. A method of limiting blood coagulation and platelet adhesion to a surface of a medical device, the method comprising:
flowing blood over the surface of the medical device, wherein the surface of the medical device is a rough surface that comprises a plurality of three-dimensionally curved features each having a radius of curvature of less than about 50 nm, and wherein the surface of the medical device comprises a sufficient concentration of features per unit area to limit blood coagulation activity on the medical device and to limit the number of platelets that adhere to the surface when the medical device is exposed to blood.