| 发明名称 |
Environmentally Responsive Microstructured Hybrid Actuator Assemblies For Use in Mechanical Stimulation of Cells |
| 摘要 |
A method for mechanical stimulation of cells includes providing a substrate comprising a plurality of microactuators embedded in an environmentally responsive hydrogel polymer layer disposed on a region of the surface; adhering at least one cell to the substrate; and exposing the environmentally responsive hydrogel polymer layer to a stimulus, the stimulus changing a volume of the environmentally responsive hydrogel polymer layer from a first volume to a second volume and thereby moving the microactuators from a first position to a second position, wherein the movement of the microactuators provides localized mechanical force directly to cells on the substrate. |
| 申请公布号 |
US2015093823(A1) |
申请公布日期 |
2015.04.02 |
| 申请号 |
US201314094152 |
申请日期 |
2013.12.02 |
| 申请人 |
President and Fellows of Harvard College |
发明人 |
SUTTON Amy Alexandra;SHIRMAN Tanya;AIZENBERG Joanna;ZARZAR Lauren;KIM Philseok |
| 分类号 |
C12M1/42;C12M1/12 |
主分类号 |
C12M1/42 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for mechanical stimulation of cells, comprising:
(a) providing a substrate comprising a plurality of microactuators embedded in an environmentally responsive hydrogel polymer layer disposed on a region of the surface; (b) adhering at least one cell to the substrate; and (c) exposing the environmentally responsive hydrogel polymer layer to a stimulus, the stimulus changing a volume of the environmentally responsive hydrogel polymer layer from a first volume to a second volume and thereby moving the microactuators from a first position to a second position, wherein the movement of the microactuators applies localized mechanical force directly to cells on the substrate. |
| 地址 |
Cambridge MA US |
