| 发明名称 |
TARGETED AND MODULAR EXOSOME LOADING SYSTEM |
| 摘要 |
Disclosed are exosomes that include a packaging protein and a cargo RNA in which the packaging protein binds specifically to the cargo RNA. The packaging protein is a fusion protein that includes an RNA-binding domain and an exosome-targeting domain. The cargo RNA includes an RNA-motif that the RNA-binding domain of the fusion protein binds specifically such that the cargo RNA is packaged in the lumen of the exosomes. |
| 申请公布号 |
US2015093433(A1) |
申请公布日期 |
2015.04.02 |
| 申请号 |
US201414502494 |
申请日期 |
2014.09.30 |
| 申请人 |
NORTHWESTERN UNIVERSITY |
发明人 |
Leonard Joshua N.;Marcus Michelle E. |
| 分类号 |
A61K47/48;C12N15/88;C12N7/00;C07K14/705;C07K14/005;A61K31/713;C12N15/85 |
主分类号 |
A61K47/48 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. Exosomes comprising a packaging protein and a cargo RNA that binds to the packaging protein. |
| 地址 |
Evanston IL US |
