GENOTYPIC AND PHENOTYPIC ANALYSIS OF CIRCULATING TUMOR CELLS TO MONITOR TUMOR EVOLUTION IN PROSTATE CANCER PATIENTS
摘要
The present invention provides methods for predicting response to a hormone-directed therapy or chemotherapy in a prostate cancer (PCa) patient comprising (a) performing a direct analysis comprising immunofluorescent staining and morphological characteristization of nucleated cells in a blood sample obtained from the patient to identify and enumerate circulating tumor cells (CTC); (b) individually characterizing genotypic, morphometric and protein expression parameters to generate a profile for each of the CTCs, and (c) predicting response to hormone-directed therapy in the prostate cancer PCa patient based on said profile. In some embodiments, the methods comprise repeating steps (a) through (c) at one or more timepoints after initial diagnosis of prostate cancer to sequentially monitor said genotypic, morphometric and protein expression parameters.
申请公布号
WO2015048740(A1)
申请公布日期
2015.04.02
申请号
WO2014US58304
申请日期
2014.09.30
申请人
THE SCRIPPS RESEARCH INSTITUTE;COLD SPRING HARBOR LABORATORY;KUHN, PETER;DAGO RODRIGUEZ, ANGEL ERNESTO;CARLSSON, ANDERS;LIU, WEI;HICKS, JIM
发明人
KUHN, PETER;DAGO RODRIGUEZ, ANGEL ERNESTO;CARLSSON, ANDERS;LIU, WEI;HICKS, JIM