发明名称 |
A QUANTITATIVE ASSAY FOR TARGET DNA IN A MIXED SAMPLE COMPRISING TARGET AND NON-TARGET DNA |
摘要 |
<p>The present disclosure relates generally to an assay to detect and quantitate target nucleic acid in a mixture of target and non-target nucleic acid, kits useful for same and its use in non-invasive diagnostic methodologies. The assay comprises identifying copy number variation (CNV) polymorphisms present in the target nucleic acid and absent in non-target nucleic acid. Embodiments disclosed include quantitating the level of fetal DNA in sample of maternal DNA and fetal DNA, and quantitating the level of donor-derived DNA in sample from a transplant recipient comprising self DNA and non-self or donor DNA.</p> |
申请公布号 |
WO2015042649(A1) |
申请公布日期 |
2015.04.02 |
申请号 |
WO2014AU00942 |
申请日期 |
2014.09.26 |
申请人 |
MURDOCH CHILDREN'S RESEARCH INSTITUTE |
发明人 |
SLATER, HOWARD ROBERT;BRUNO, DAMIEN LUIS;GANESAMOORTHY, DEVIKA |
分类号 |
C12Q1/68 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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