发明名称 BORATE MOIETY-CONTAINED LINKER AND BIO-SENSING ELEMENT CONTAINING THE SAME
摘要 A borate moiety-contained linker and a bio-sensing element containing the same are disclosed. The borate moiety-contained linker can be used to modify a sensing molecule and connect the sensing molecule to a substrate to form the bio-sensing element.
申请公布号 US2015094469(A1) 申请公布日期 2015.04.02
申请号 US201414559934 申请日期 2014.12.04
申请人 NATIONAL CHIAO TUNG UNIVERSITY 发明人 LI Yaw-Kuen;SHEN Mo-Yuan;PIEN Yu-Ju
分类号 C07F5/02;G01N33/543 主分类号 C07F5/02
代理机构 代理人
主权项 1. A borate moiety-contained linker for modifying a sensing molecule and connecting the sensing molecule to a substrate, the linker comprising a compound having a structure represented by the following chemical formula (I):wherein R1 is one of the following chemical structures: X is selected from the group consisting of ester bond (—COO— and —OCO—), 1,3-succinimide bondand triazole bondand L and Z are independently selected from the group consisting of amide bond (—CONH— and —NHCO—), ester bond (—COO— and —OCO—), 1,3-succinimide bondand triazole bondand X, Z end L are different to each other, Y is thiol group (—SH), amine group (—NH2), azido group (—N3), carboxylic acid group (—COOH) or disulfide-contained group (—S—S—R2), R2 is pyridineor 1,2-dithiolane-contained group R3 is methylene group (—CH2—) or N-(3H-1,2-triazo)-4-methyl pentanamide R4 is hydrogen (H) or nitro group (—NO2), m is an integral from 1 to 10, n is an integral from 0 to 10, and o is 1 or 2.
地址 Hsinchu City TW