FUSED 2-AMINOTHIAZOLE COMPOUNDS

摘要

The present application relates to therapeutic organic compounds, compositions comprising an effective amount of a therapeutic organic compound; and methods for treating and preventing disease comprising administering and effective amount of a therapeutic organic compound to a subject in need thereof.

主权项

1. A compound of the Formula I: and pharmaceutically acceptable salts, enantiomers, stereoisomers, rotamers, tautomers, diastereomers, or racemates thereof; wherein Q is CH or N; R1 is H, C(O)—C3-6-cycloalkyl, aryl, heteroaryl, C(O)N(H)-heteroaryl, C(O)-heteroaryl, C(O)-heterocycle, C(O)-aryl, C(O)—C1-6-alkyl, CO2—C1-6-alkyl, C3-6-cycloalkyl, or C(O)—C1-6-alkyl-heterocycle, wherein the aryl or heteroaryl groups can be substituted or unsubstituted; R2 is H, C1-6-alkyl, C1-6-alkoxy, or halogen; R3 is H, C(O)—N(H)-aryl, C(O)—N(H)—C1-6-alkyl-heterocycle, C(O)—N(H)—C1-6-alkyl-heteroaryl, wherein the aryl, heteroaryl or heterocycle groups can be substituted or unsubstituted; and R4 is C(O)N(H)—C1-6-alkoxy or NH2.