SYSTEMS AND METHODS FOR CHARACTERIZING A MOLECULE

摘要

Techniques for characterizing a molecule are described herein. In one example, a portion of the molecule is trapped in a nanopore, a variable voltage is applied across the nanopore until the trapped portion of molecule is moved within the nanopore, and the molecule is characterized based on the electrical stimulus required to affect movement of at least a portion of the trapped portion of the molecule within the nanopore.

主权项

1. A method analyzing a plurality of molecules, comprising:
(a) forming a plurality of individually addressable nanopore devices on a chip, each individually addressable nanopore device of said plurality of individually addressable nanopore devices containing at least one nanopore formed in a membrane disposed adjacent to an electrode, each individually addressable nanopore device being addressable using row and column addressing; (b) directing a plurality of molecules to said individually addressable nanopore devices; and (c) analyzing, with the aid of a processor coupled to said chip, at least a portion of each of said molecules based on electrical signals received from said plurality of individually addressable nanopore devices.