Chimeric Multivalent Polysaccharide Conjugate Vaccines

摘要

The present invention provides multivalent chimeric conjugate vaccine molecule and methods of using the conjugate to immunize subjects against bacterial infections. A conjugate molecule of the invention comprises multiple bacterial capsular polysaccharides linked to a carrier protein. Accordingly, the conjugate molecule provides immune protection against multiple types of bacteria in a single vaccines. In particular, conjugate molecules of the invention are used to prevent or attenuate Group B Streptococcus and meningococcal infections.

主权项

1. A multivalent conjugate molecule comprising a carrier protein with bacterial capsular polysaccharides obtained from at least three different types of bacterial capsular polysaccharides covalently linked to the carrier protein, wherein the molecule elicits protective antibodies to each of said different bacterial capsular polysaccharides.