发明名称 |
Therapies based on control of regulatory T cell stability and function via a Neuropilin-1:Semaphorin axis |
摘要 |
The invention is directed to treatment of cancer, infections and various inflammatory and autoimmune conditions by affecting regulatory T cell stability and function via a Neuropilin-1 :Semaphorin axis. The present invention satisfies this and other needs by demonstrating that the regulatory T cell (Treg)-restricted neuropilin-1 (Nrp 1) interacts with the cell surface ligand semaphorin-4a (Sema4a) (e.g., on conventional T cells (Tconv), conventional dendritic cells (cDCs), and/or plasmacytoid dendritic cells (pDCs)) to potentiate reg function and enhance their survival at inflammatory sites. |
申请公布号 |
AU2013329372(A1) |
申请公布日期 |
2015.04.02 |
申请号 |
AU20130329372 |
申请日期 |
2013.10.08 |
申请人 |
ST. JUDE CHILDREN'S RESEARCH HOSPITAL |
发明人 |
VIGNALI, DARIO A. A.;WOO, SENG-RYONG;DELGOFFE, GREG M. |
分类号 |
A61K38/17;A61P37/02 |
主分类号 |
A61K38/17 |
代理机构 |
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代理人 |
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地址 |
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