Differential loading of drug-eluting medical devices

摘要

DIFFERENTIAL LOADING OF DRUG-ELUTING MEDICAL DEVICES A medical device includes a substrate having at least one surface. The surface has a central portion (24) and a peripheral portion (26). At least one bioactive agent is disposed over at least a portion of the surface. The medical device having a concentration gradient of the at least one bioactive (22) between the central and peripheral portions.