BIODEGRADABLE POLYMERS WITH PENDANT FUNCTIONAL GROUPS ATTACHED THROUGH AMIDE BONDS

摘要

Amide compounds are defined and are polymerized to create polyesters and polyurethanes having amide units bearing a pendant functional group, where the nitrogen atom of the amide group is part of the polymer backbone. The pendant functional group of the functionalized amide polymer may be modified or added by post polymerization functionalization of the functionalized amide polymer. The pendant functional group of the functionalized amide polymer may include a protecting group that may be removed after polymerization. The pendant functional groups of the functionalized amide polymers may be used to modulate the physical, chemical and biological properties of the polymers.

主权项

1. A functionalized amide polymer according to the following structure: where every Xc is a urethane group or every Xc is an ester group; R1 and R2 may be the same or different and are each hydrocarbon groups; and where R1 and R2 may be selected to join to create a heterocyclic group that includes the nitrogen atom as a hetero atom within the heterocyclic group, R4 is a hydrocarbon group, m and n represent repeating units of the polymer in random or block configuration, M1 and M2 are pendant functional groups.