发明名称 |
MEDICAL DEVICE COATINGS FOR RELEASING A THERAPEUTIC AGENT AT MULTIPLE RATES |
摘要 |
Medical device coatings are provided that simultaneously release a therapeutic agent at different rates from different portions of the medical device coating. In a first embodiment, medical device coatings are provided that include particles comprising a therapeutic agent with two or more different particles sizes within a single layer on a surface of the implantable device. In a second embodiment, medical device coatings are provided having a higher concentration of the therapeutic agent in a first region of the coating than in a second region of the coating. In a third embodiment, medical device coatings are provided that are formed by certain coating processes wherein the droplet size of a spray coating solution is changed during the coating process. These coating processes preferably include applying a solution comprising a therapeutic agent and a suitable solvent to a surface of an implantable medical device. In a fourth embodiment, methods of treatment are provided that include implanting a coated medical device. |
申请公布号 |
US2015093496(A1) |
申请公布日期 |
2015.04.02 |
申请号 |
US201414564604 |
申请日期 |
2014.12.09 |
申请人 |
COOK MEDICAL TECHNOLOGIES LLC |
发明人 |
Moore William F.;Shirley Gary Bradford |
分类号 |
A61L31/08;A61L29/08;A61L29/16;A61L31/16 |
主分类号 |
A61L31/08 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
BLOOMINGTON IN US |