FUSED PROTEINS OF GRANULOCYTE COLONY-STIMULATING FACTOR WITH OTHER PARTNERS OF GROWTH FACTOR, PREFERABLY WITH STEM CELL FACTOR, AND METHOD OF PREPARATION THEREOF

摘要

Abstract Invention is disclosing method for preparation and biological properties of fused proteins, mainly heterodimer of granulocyte colony-stimulating factor and stem cell factor. Multimer constructions according to this invention may be used in therapy, since are characterized by synergy of in vivo functioning and extended circulation half-life in comparison to each separate protein monomer.