COMPOSITE PARTICLES, DERIVED CONJUGATES, PREPARATION METHOD THEREOF AND APPLICATIONS OF SAME

摘要

Composite particles comprising inorganic nanoparticles and a core in hydrophobic polymer (I) which forms a polymeric matrix in which the nanoparticles are stabilized and distributed homogeneously, the particles being characterized in that they are at least partially surrounded by an amphiphilic copolymer comprising a hydrophilic part and a hydrophobic part which is at least partially immobilized on or in the polymeric matrix, are new. An Independent claim is also included for the preparation of the above particles where the hydrophobic part of the amphiphilic copolymer is at least partially immobilized in the polymeric matrix, by: (a) obtaining a stable and isodisperse starting emulsion consisting of two immiscible phases: hydrophobic phase A consisting of droplets containing inorganic nanoparticles dispersed in an organic phase containing a surfactant; and (b) hydrophilic phase B in which A is dispersed; (c) adding hydrophobic monomers into phase B and at least one initiating agent; and (d) polymerizing the hydrophobic monomers in phase A, the process being characterized by addition of at least one amphiphilic copolymer to phase B prior to step (c).